August 30, 2017: PhD public defence - Bjorn Baselet - Molecular characterization of endothelial cell response in the context of radiation-induced atherosclerosis - UCL

Name: Bjorn Baselet

Date: August 30, 2017 16:00 h

Venue: 

UCL
Auditorium Maisin
Avenue E. Mounier 51
1200 Woluwe-Saint-Lambert

 

Molecular characterization of endothelial cell response in the context of radiation-induced atherosclerosis

Ionizing radiation is used for radiotherapeutic and diagnostic purposes, which can expose the heart and blood vessels, potentially causing cardiovascular diseases (CVDs). However, dose-dependency and associated molecular mechanisms are still elusive.

Our work focused on endothelial cells based on previous information suggesting that ionizing radiation could promote atherosclerosis. We report that a single X-ray dose induces a time- and dose-dependent pro-atherosclerotic phenotype, linked with changes in cell cycle progression and induction of inflammation and senescence. By comparing responses to X-rays and Fe ion, radiation impact was found to be dependent on radiation quality, with a more pronounced and longer lasting response to Fe ions.

Altogether, our data provide new molecular information on the causes of radiation-induced CVD and a basis on which to build new knowledge in order to ameliorate the current radiation protection system.

 

Promotors:
  •  (UCL) Sonveaux Pierre
SCK•CEN mentors:
  • An Aerts

Click here for a list of obtained PhD degrees.