Name: Bjorn Baselet
Date: August 30, 2017 16:00 h
Avenue E. Mounier 51
Molecular characterization of endothelial cell response in the context of radiation-induced atherosclerosis
Ionizing radiation is used for radiotherapeutic and diagnostic purposes, which can expose the heart and blood vessels, potentially causing cardiovascular diseases (CVDs). However, dose-dependency and associated molecular mechanisms are still elusive.
Our work focused on endothelial cells based on previous information suggesting that ionizing radiation could promote atherosclerosis. We report that a single X-ray dose induces a time- and dose-dependent pro-atherosclerotic phenotype, linked with changes in cell cycle progression and induction of inflammation and senescence. By comparing responses to X-rays and Fe ion, radiation impact was found to be dependent on radiation quality, with a more pronounced and longer lasting response to Fe ions.
Altogether, our data provide new molecular information on the causes of radiation-induced CVD and a basis on which to build new knowledge in order to ameliorate the current radiation protection system.
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