The aim of this study is to quantify the biodistribution of gold nanoparticles in a wild-type mouse model. mAb-AuNPs@PPAA will be injected in normal wild-type mice. Different time points after injection, the liver, spleen, lungs, brain, kidneys and the blood will be the main targets to be studied. The concentration of gold in these tissues will be analysed quantitatively by ICP-MS. The master student will develop and optimize the tissue digestion process and the operating parameters to create accurate and reproducible quantitative measurements. Furthermore, the student will learn how to construct an in vivo pharmacokinetic profile of the AuNP nanoconjugate.
This master thesis is a collaborative project with the Radiobiology and Radiochemistry groups of the Studiecentrum voor Kernenergie (SCK•CEN) at Mol (Belgium). The student is expected to carry out all of the experimental work at SCK•CEN. SCK•CEN can provide appropriate accommodation for the student if required.