August 27, 2019: PhD public defense - Michiel Van de Voorde - Supported ionic liquid phases for the extraction and separation of medical radiolanthanides - Towards purification of medical samarium-153 - KULeuven

Name: Michiel Van de Voorde

Date: August 27, 2019

Venue:

Auditorium Kasteel Arenberg, room 01.07
KU Leuven Campus Heverlee
Kasteelpark Arenberg 1
3000 Leuven


 

Supported ionic liquid phases for the extraction and separation of medical radiolanthanides - Towards purification of medical samarium-153

Radioisotopes are an important tool in nuclear medicine in the fight against cancer. Several radiolanthanides show favorable decay properties for being  used in therapy and/or diagnosis, and can be efficiently produced in a nuclear research reactor. Depending on the production pathway followed, the radiolanthanide requires separation from its target material or long-lived impurities prior to its use in medicine. 

In this PhD project, a new separation method was investigated to remove long-lived europium-154 impurities from the medically interesting samarium-153. To improve the separation efficiency between both lanthanides, europium(III) was reduced to europium(II) in a first step. It was discovered that this reduction was also feasible in concentrated nitrate media, which was therefore studied in more detail. In a second step, samarium(III) and europium(II) were separated by selectively extracting samarium(III) to an ionic liquid phase. Immobilization of this ionic liquid onto an inert support led to the generation of a supported ionic liquid phase, which could be used as a stationary phase in extraction chromatography. The developed method proved to be promising for efficient separation of samarium and europium, and can be considered for application in the purification of medical samarium-153.

 

 

Promotors:
  • (KULeuven) Koen Binnemans
  • (KULeuven - SCK•CEN) Thomas Cardinaels
SCK•CEN mentor:
  • Karen Van Hecke

Click here for a list of obtained PhD degrees.