The similar chemical properties of lanthanides allow for similar radiolabeling approaches in radiopharmaceutical production. On the other hand, this characteristic inhibits the easy separation of neighboring lanthanides. Therefore, to achieve an efficient separation and isolation of 161Tb the strategy will be changing the chemical properties of Tb(III) by oxidizing it to Tb(IV) as a preparative step.
The objective of this master thesis project is to gain fundamental insight in the redox chemistry of Tb and broaden the limited knowledge on the Tb(IV) stabilization. Due to the high chemical stability of Tb(III) and to avoid contamination via strong oxidation agents, electrochemical methods (chronoamperometry, cyclic voltammetry) will be applied to perform the oxidation. To further analyze the oxidation efficiency and stability due to a variety of parameters (solvent, supporting electrolyte, pH…), analytical methods such as UV-Vis spectroscopy and ICP-MS will be used.